Diabetes & Other Endocrine and Metabolic Disorders
Disorders Affecting the Adrenal Glands
Adrenal glands, which are also called suprarenal glands, are small, triangular glands located on top of both kidneys. An adrenal gland is made of two parts: the outer region, called the adrenal cortex, and the inner region, called the adrenal medulla. The adrenal glands work interactively with the hypothalamus and pituitary gland, as well as secrete hormones that affect metabolism, blood chemicals, and certain body characteristics. Adrenal glands also secrete hormones that help a person cope with both physical and emotional stress.
Hormones secreted by the adrenal glands include the following:
- adrenal cortex
- corticosteroid hormones (hydrocortisone or cortisol) - to help control
the body's use of fats, proteins, and carbohydrates, suppress inflammatory
reactions in the body, and affect the immune system function.
- aldosterone - inhibits the level of sodium excreted into the urine,
and maintains blood volume and blood pressure.
- androgenic steroids (androgen hormones) - hormones that have an effect on the development of male characteristics.
- corticosteroid hormones (hydrocortisone or cortisol) - to help control
the body's use of fats, proteins, and carbohydrates, suppress inflammatory
reactions in the body, and affect the immune system function.
- adrenal medulla
- epinephrine (adrenaline) - increases the heart rate and force of
heart contractions, facilitates blood flow to the muscles and brain,
causes relaxation of smooth muscles, helps with conversion of glycogen
to glucose in the liver, and other activities.
- norepinephrine (noradrenaline) - this hormone has little effect on smooth muscle, metabolic processes, and cardiac output, but has strong vasoconstrictive effects (narrowing of the blood vessels), thus, increasing blood pressure.
- epinephrine (adrenaline) - increases the heart rate and force of
heart contractions, facilitates blood flow to the muscles and brain,
causes relaxation of smooth muscles, helps with conversion of glycogen
to glucose in the liver, and other activities.
Certain adrenal gland disorders are characterized by an inability of the adrenal glands to produce cortisol (also known as hydrocortisone hormone) and aldosterone, often due to certain missing enzymes (proteins that speed up or cause chemical reactions). The result is enlarged adrenal glands due to overstimulation from the hypothalamus which detects the low levels of hormones. The hypothalamus, in turn, stimulates the pituitary gland to stimulate the adrenal glands. Overstimulation of the adrenal glands can lead to overproduction of androgens, which can lead to masculinization.
Disorders of the adrenal glands require clinical care by a physician or other healthcare professional. Listed in the directory below are some of these disorders, for which we have provided a brief overview.
If you cannot find the information in which you are interested, please visit the Diabetes & Other Endocrine and Metabolic Disorders Online Resources page in this Web site for an Internet/World Wide Web address that may contain additional information on that topic.
| Underactive Adrenal Glands / Addison's Disease |
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Contact Information
Jennifer Amaral
Endocrinology and DiabetesStephen W. Ponder, M.D. C.D.E. - Medical Director
Endocrinology and DiabetesChildren's Diabetes and Endocrine Center
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3533 S. Alameda St.
Corpus Christi, TX 78411
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